Capillogain® Tonic

israelite · Post by **israelite** » Mon Mar 04, 2013 8:44 am

Friday wrote:
israelite wrote:they should notify every who got this batch! the first batch was good no need to experiment.
I got this batch a month ago, and I haven't been notified.. oh, and I don't think anyone's experimenting, I'm using minox and capillogain, I'm not mixing it together..

Not u . The makers of capillogain are.

israelite · Post by **israelite** » Tue Mar 05, 2013 2:29 am

SyntheseLabRat do u still work for the company?

SyntheseLabRat · Post by **SyntheseLabRat** » Tue Mar 05, 2013 2:02 pm

My colleagues informed me, that they will contact the majority of our customers who have bought bottles from the batch with the batch number (Losnr.) 3120005, at least those of whom we know the email address or are able to reach them via amazon. We will just send them new bottles for free and they won´t have the hassle with sending back the old used ones. If you have bottles from the batch with the batch number (Losnr.) 3120005 and haven´t received an email from us by tomorrow, please feel free to contact us at service@functional-products.net. Of course you can contact us for any other question any time, too.

SyntheseLabRat · Post by **SyntheseLabRat** » Tue Mar 05, 2013 2:03 pm

israelite wrote:SyntheseLabRat do u still work for the company?

Yes, I still work for them.

Jacob · Post by **Jacob** » Tue Mar 05, 2013 4:54 pm

SyntheseLabRat wrote:My colleagues informed me, that they will contact the majority of our customers who have bought bottles from the batch with the batch number (Losnr.) 3120005, at least those of whom we know the email address or are able to reach them via amazon. We will just send them new bottles for free and they won´t have the hassle with sending back the old used ones. If you have bottles from the batch with the batch number (Losnr.) 3120005 and haven´t received an email from us by tomorrow, please feel free to contact us at service@functional-products.net. Of course you can contact us for any other question any time, too.

I found a subatomic particle in mine

kamisama · Post by **kamisama** » Wed Mar 06, 2013 7:04 am

Can i know if i were to buy from amazon.com now, is the batch there a good batch?

SyntheseLabRat · Post by **SyntheseLabRat** » Wed Mar 06, 2013 5:01 pm

kamisama wrote:Can i know if i were to buy from amazon.com now, is the batch there a good batch?

You can buy from amazon.com.
As far as I know no single bottle of the batch in question went to amazon.com.

SyntheseLabRat · Post by **SyntheseLabRat** » Sat Mar 09, 2013 7:01 am

Capillogain Shampoo is now available at amazon.com:

http://www.amazon.com/Capillogain%C2%AE ... apillogain

rosariorose9 · Post by **rosariorose9** » Sun Mar 10, 2013 5:58 pm

The tonic is very reasonably priced, but the shampoo is, imho, prohibitively expensive.

Aks20 · Post by **Aks20** » Mon Mar 11, 2013 12:27 am

I used Cap tonic and shampoo over a little over two weeks, so here are my observations.

This product is great for those who can tolerate Minoxidil. Simply put Triaminodil + encapsulation in Capillogain much stronger than 5% Minox. At least for me.

Regimen

1nce a day (nighttime) application of Cap.tonic 2 pumps of the pipette.
Morning, 1nce a day, shampoo with Cap shampoo

My first ten days

- Huge reduction in shedding
- No noticeable regrowth
- No noticeable side effects
- Scalp itch disappeared/reduced massively

Based on the massive reduction in hair loss itself, I really liked the product. Since even hair were I didnt apply Cap was not shedding. I think it could be due to Triaminodil effect as well. But even otherwise, my itching reduced, so it could be the other ingreds as well.

I stopped for 2 days as I had a bad cold and didnt want to shampoo those 2 days and get my hair wet. Without shampoo, one cannot use this, as it was pretty sticky, the tonic that is.

When I restarted, out came the sides.

First, massive headache for two days. Crocin didnt work, neither did relaxing/stopping physical exertion.

Pounding heart. Generally fast heart rate even when relaxing (no activity).

Finally, got my BP checked. It was very low. The doctor did not give me the measurement so as to not concern me or make me feel worried (it was evening & I was asked to rest), but was clearly taken aback by the fact that even when measuring my pulse (wrist), the beat had dropped significantly. It took 2-3 days and now I feel a bit ok but BP is still lower than normal. The headache is apparently another side effect of lowered Blood pressure.

Net, the triaminodil is either stronger than Minox or the liposomal delivery % of even the 0.5% gets it much quicker into the skin & of course, it goes systemic thereafter.

I had similar effects with Minox after several months use but not this strong. But the pounding heart itself made me stop. Plus the fact I looked like a zombie on Minox - bad skin, dark circles under the eyes.

Here, its just been the rapid effect on BP.

Don't get me wrong. I like the product, I think the people making it are sincere and have done their bit. But for those susceptible to sides with Minox, this is the same deal.

I would love to try it without the Triaminodil. I think it will still be a good product.

As I mentioned, it has taken away my scalp itch. That may be due to the other ingredients as well, and not just the Triaminodil.

Lastly, I have the same lot number being discussed here (as flawed/has an issue etc) ending with zero-five.

But - no libido related issues (were there with S-Equol). No brain fog/tiredness etc. which people claim is an issue with DHT reducing products. Again, 2 weeks is less time for judging these but none of these sides.

If it were to be made without Triaminodil, I would buy it. For those of you who can stand Minox and have no issues, this is probably a better deal.

SyntheseLabRat · Post by **SyntheseLabRat** » Mon Mar 11, 2013 2:27 am

@Aks20

If you have a cold your blood pressure is likely low due to your illness. After 2 days you are likely not fully recovered even when you feel more or less ok again. Headache is usually also a side of a cold. And if you are at rest your blodd pressure is supposed to be low.
I am confused by your statement "pounding heart" but on the other hand you report about reduced beat rate.
My advice to you, start with the Shampoo first again, it seems to help your scalp itch and I think you won´t get any problem. When you think you are fully recovered from your cold, try the Tonic again (your new bottles). If you haven´t been contacted already, please write to service@functional-products.net ,you will get new bottles for your 05-bottles.

I personally can confirm the observation of itch reduction with the Shampoo. In the past I thought my scalp problem was dandruff due to this pesky fungus and I mainly treated it with Ket-Shampoos but it seems that a big part of my dandruff and itchy scalp problem was due to a reaction to the aggressive surfactants in common Shampoos.
I agree on the price, I hope we will be able to produce and sell it cheaper in the future.

Aks20 · Post by **Aks20** » Mon Mar 11, 2013 4:47 am

Hi Synthese, i thought of that, but it became clear that the headache was not cold related since I had recovered by then and was not having any headache. For my usual cold/light viral infections, crocin and painkillers work fine.

My cold was basically a running nose and constant allergy i just didnt want to get it worse.

Anyways headache, was definitely due to blood pressure. As my BP went up (stabilized to normal levels), the headache went away. One of the things I forgot to mention, it came on immediately after i applied capillogain tonic. That was the smoking gun. Within half a hour, i felt dizzy and had a pretty bad headache. The second time it occurred, it was after that i had my BP checked.

In terms of pounding heart, its is what happens when you have Low BP, your heart basically has to struggle that much more to push the blood through, so if you exert yourself, your heart rate goes way up. Even in certain positions though you are not exercising the same occurs. However, if you are not stressing, then the BP will read very low, which is what happened when my doctor checked my BP. After I told the symptoms, the next step was checking the BP which came out as shown.

The point is that even after 2 days i didnt recover fully, shows the triaminodil was/is still in my system. This was one of the similar reasons i quit minox as well. With minox, activities like climbing some 3-4 flights of stairs, which i could normally do without an issue, would result in heart rate suddenly increasing. As you'd know, Minox is a powerful vasodilator and triaminodil seems to be very similar.

Aks20 · Post by **Aks20** » Mon Mar 11, 2013 6:38 am

Similar sides for other guys sensitive to Minox....we unlucky dudes...

http://www.baldtruthtalk.com/showthread ... 77&page=15

Conpecia
Senior Member

Join Date: Sep 2011
Posts: 340

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Just a quick update: have applied this twice in the past 24 hours and must be using way too much because I'm getting pretty bad headaches. Gonna take a day or two off then start back up with much smaller amounts, probably every other day until I'm used to it. Wish I wasn't so god damn sensitive to these meds...

Conpecia
Senior Member

Join Date: Sep 2011
Posts: 340

Default
Just applied a much lower 3rd application. Sides so far after 3 applications:

Warmness in the treatment areas
Itching in the treatment areas
Headaches similar to a caffeine headache (had these with Kirkland minox foam but not Rogaine foam)

One of the natural DHT blockers may also be irritating my gyno, as I've been off fin a good 3 weeks but am still experiencing achiness that may have gotten worse the past 3 days, not sure.

At this point I will not continue with this treatment if these sides don't lessen after two weeks. I do expect them to lessen once my head gets adjusted to the dosage.

Campbell22
Junior Member

Join Date: Feb 2013
Posts: 19

Default
I got a really bad headache yesterday as well which is really unusual for me and I'm one of the ones that had a dubious batch. Makes sense

israelite · Post by **israelite** » Mon Mar 11, 2013 9:05 pm

results are still getting bvetter with capillogain. i added customs topicals recently hoping for synergy effect.

HairyHarry · Post by **HairyHarry** » Tue Mar 12, 2013 2:57 am

I had the same problem with the headaches. It started right away (approximately half an hour after applying) and it stayed during the day. It was never an unbearable headache, but it was always there, and if I would have a hard day at work, it would become worse. So, that's why I quit the cap... Really looking forward to a version WITHOUT triaminodil, as the other ingredients are still very good.

SyntheseLabRat · Post by **SyntheseLabRat** » Tue Mar 12, 2013 2:05 pm

Aks20 wrote:Hi Synthese, i thought of that, but it became clear that the headache was not cold related since I had recovered by then and was not having any headache. For my usual cold/light viral infections, crocin and painkillers work fine.

My cold was basically a running nose and constant allergy i just didnt want to get it worse.

Anyways headache, was definitely due to blood pressure. As my BP went up (stabilized to normal levels), the headache went away. One of the things I forgot to mention, it came on immediately after i applied capillogain tonic. That was the smoking gun. Within half a hour, i felt dizzy and had a pretty bad headache. The second time it occurred, it was after that i had my BP checked.

In terms of pounding heart, its is what happens when you have Low BP, your heart basically has to struggle that much more to push the blood through, so if you exert yourself, your heart rate goes way up. Even in certain positions though you are not exercising the same occurs. However, if you are not stressing, then the BP will read very low, which is what happened when my doctor checked my BP. After I told the symptoms, the next step was checking the BP which came out as shown.

The point is that even after 2 days i didnt recover fully, shows the triaminodil was/is still in my system. This was one of the similar reasons i quit minox as well. With minox, activities like climbing some 3-4 flights of stairs, which i could normally do without an issue, would result in heart rate suddenly increasing. As you'd know, Minox is a powerful vasodilator and triaminodil seems to be very similar.

A cold isn´t gone in 2 days. But maybe you are really very sensitive to Minoxidil/Triaminodil. However, I think you should try the Shampoo again after a few days when your cold is really gone. And try your new bottle from the new batch, too.

SyntheseLabRat · Post by **SyntheseLabRat** » Tue Mar 12, 2013 6:10 pm

Some information on Capillogain Shampoo.

Capillogain® Shampoo is a new innovation on the world market with scientifically backed hair growth promoting active agents.

Capillogain® Shampoo is the world´s first Shampoo that managed to combine our microencapsulating technique with a Shampoo. The innovative dermal delivery carrier (vehicle) microencapsulates the active agents and transports them directly to the hair follicles. The sustained release of the active agents over a long period from the vesicles leads to a prolonged high concentration of the active agents at the site of the hair follicles which leads to a higher effectiveness compared to plain Shampoos without microencapsulating technology. Therefore Capillogain® Shampoo doesn´t need any penetration enhancers that may irritate the skin. We uploaded a light-microscope photo of the tiny vesicles in Capillogain® Shampoo here:
http://www.functional-products.net/index.php?id=110

Capillogain® Shampoo does not contain any sulfates, parabens, silicones, artificial colors, and artificial fragrance.

Capillogain® Shampoo contains exclusively mild surfactants and has a skin-friendly pH-value which allows for a prolonged contact time without irritation of the scalp which in turn leads to a more effective penetration of the active agents before the Shampoo is rinsed off.

Capillogain® Shampoo is suitable for daily hair wash.

Capillogain® Shampoo was developed with complementary active agents as a supplementation of our popular Capillogain® Tonic. A reliable application routine consists of Capillogain® Tonic in the evening and Capillogain® Shampoo in the morning.

Below we list the active agents of Capillogain® Shampoo and briefly mention their mechanisms of action.

Active agents in Capillogain® Shampoo

Triaminodil® (Proderma S.r.l. - Italy)
poster P-186 on page 93:
http://www.nahrs.org/home/Portals/0/mee ... ristol.pdf
http://www.ncbi.nlm.nih.gov/pubmed/21689115
Triaminodil-Monograph (contains several clinical trials):
http://www.functional-products.net/uplo ... pdated.pdf
recent clinical study (the product Aminotril also contains the active agent Triaminodil):
http://www.functional-products.net/uplo ... pdated.pdf

Green Tea Extract (Epigallocatechin Gallate [EGCG])
EGCG down-regulates the expression of the androgen receptor:
http://www.ncbi.nlm.nih.gov/pubmed/22505206
http://www.ncbi.nlm.nih.gov/pubmed/21177307
http://www.ncbi.nlm.nih.gov/pubmed/10773882
http://www.ncbi.nlm.nih.gov/pubmed/18977589
Quote from the below linked article:
“By Western blot analysis, EGCG and quercetin used alone inhibited the AR expression by 55% and 75%, respectively, compared to the control, whereas genistein surprisingly elevated the AR levels by ~2.45-fold (Figure 3C).”
http://www.ncbi.nlm.nih.gov/pubmed/19846946
Quote from the below linked article:
“We investigated the effect of topical epigallocatechin-3-gallate (EGCG) on testosterone (T)-induced hair loss in mice. Marked hair loss was observed at the T-injected site, and topical EGCG significantly reduced the hair loss (P<0.05).”
http://www.ncbi.nlm.nih.gov/pubmed/21951062
Quote from the below linked article:
“Recently, it was reported that EGCG might be useful in the prevention or treatment of androgenetic alopecia by selectively inhibiting 5alpha-reductase activity. However, no report has been issued to date on the effect of EGCG on human hair growth. This study was undertaken to measure the effect of EGCG on hair growth in vitro and to investigate its effect on human dermal papilla cells (DPCs) in vivo and in vitro. EGCG promoted hair growth in hair follicles ex vivo culture and the proliferation of cultured DPCs. The growth stimulation of DPCs by EGCG in vitro may be mediated through the upregulations of phosphorylated Erk and Akt and by an increase in the ratio of Bcl-2/Bax ratio. Similar results were also obtained in in vivo dermal papillae of human scalps. Thus, we suggest that EGCG stimulates human hair growth through these dual proliferative and anti-apoptotic effects on DPCs.“
http://www.ncbi.nlm.nih.gov/pubmed/17092697
Quote form the below linked article:
“Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders.”
http://www.ncbi.nlm.nih.gov/pubmed/11380153
EGCG prevents also hair loss in the inner ear (ototoxicity). However, the in the below quote mentioned INF-gamma is also a potent hair loss inducer for scalp hair.
Quote from the below linked article:
“Treatment with IFN-gamma, which also causes STAT1 activation, also induced hair cell death in wild-type but not STAT1-deficient mice. These results show that STAT1 is required for maximal cisplatin-induced hair cell death in the mouse utricle and suggest that treatment with EGCG may be a useful strategy for prevention of cisplatin ototoxicity.”
http://www.ncbi.nlm.nih.gov/pubmed/19321781
EGCG counteracts ototoxicity also by suppressing the activation of caspase-1 and caspase-3. Both caspases are known to play a negative role in androgenetic alopecia.
Quotes from the below linked article:
“However, EGCG counteracted this ototoxicity by suppressing the activation of caspase-3/NF-κB and preventing the destruction of hair cell arrays in the organ of Corti.”
“We have shown, for the first time, that EGCG is effective in preventing the destruction of hair cell arrays and apoptosis both in vitro and ex vivo. EGCG is also effective in counteracting ototoxicity by suppressing NF-κB and caspase-1 activation.”
http://www.ncbi.nlm.nih.gov/pubmed/23028481
Quote from the below linked article:
“Caspase-1 is expressed in normal human adult epidermal keratinocytes. Caspase-1 expression is greater in men with AGA.“
http://www.ncbi.nlm.nih.gov/pubmed/22404322
Quote from the below linked article:
“Caspases 1, 3, 8 and 9 were detected predominantly within the isthmic and infundibular hair follicle area for both normal and AGA patients, however the expression of all factors, especially caspase 3 was greater in the AGA group than in the normal scalp group. AGA men had the same caspase factors but with greater expression.”
http://www.ncbi.nlm.nih.gov/pubmed/11399535
Quote from the below linked article:
“Constitutive expression of caspases-1, -3, -8, and -9 and XIAP was detected predominantly within the isthmic and infundibular hair follicle area, basilar layer of the epidermis, and eccrine and sebaceous glands. AGA-affected tissues showed an increase in caspase (-1, -3, -6, -9) immunoreactivity with a concomitant decrease in XIAP staining.“
http://www.ncbi.nlm.nih.gov/pubmed/11896416
Anti-inflammatory action:
http://www.ncbi.nlm.nih.gov/pubmed/22763784
Potent antioxidant effect:
http://www.ncbi.nlm.nih.gov/pubmed/22000973
http://www.ncbi.nlm.nih.gov/pubmed/23292326

Garden Burnet Root Extract (Sanguisorba Officinalis Root Extract)
Fibroblast growth factor 5 (FGF-5) is a signaling protein. The findings form the below linked article show that FGF-5 functions as an inhibitor of hair elongation.
http://www.ncbi.nlm.nih.gov/pubmed/7923352
The disruption of FGF-5 expression in mammals increases the length of the anagen phase (growth phase) of the hair cycle, resulting in a phenotype of extremely long hair. This so-called angora mutation has been shown in many species, like cats, dogs, mice, rabbits, sheep and goats:
http://www.ncbi.nlm.nih.gov/pubmed/17767004
http://www.ncbi.nlm.nih.gov/pubmed/17433015
http://www.ncbi.nlm.nih.gov/pubmed/19713490
http://www.ncbi.nlm.nih.gov/pubmed/7923352
http://www.ncbi.nlm.nih.gov/pubmed/18779133
http://www.ncbi.nlm.nih.gov/pubmed/22444694
Quote from the below linked article:
“Angora is an autosomal recessive mouse mutation caused by a deletion of approximately 2 kilobases in the fibroblast growth factor 5 (Fgf5) gene. Phenotypically, homozygous angora (Fgf5go/Fgf5go) mice have excessively long truncal hair and can be differentiated from heterozygous (+/Fgf5go) and wild-type (+/+) littermates by 21 days of age. Abnormal hair length is due to a prolongation of the anagen phase of the hair cycle of approximately 3 days.“
http://www.ncbi.nlm.nih.gov/pubmed/9163872
Quotes from the below linked article:
“The hair cycle is regulated by various molecules, among which FGF-5 has been shown to promote the transition from anagen to catagen. The FGFR-1, a trans-membrane receptor of FGF-5 with tyrosine kinase activity, is localized in the follicular papilla of hair follicles.“
“These results suggest the clinical utility of antisense nucleotide targeting FGFR-1 as a treatment for baldness.”
http://www.ncbi.nlm.nih.gov/pubmed/17343580
Title of the below linked article:
“Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation.”
http://www.ncbi.nlm.nih.gov/pubmed/11779149
Additional publications that describe the catagen inducing effect of FGF-5 in hair growth:
http://www.ncbi.nlm.nih.gov/pubmed/10393176
http://www.ncbi.nlm.nih.gov/pubmed/10692103
http://www.ncbi.nlm.nih.gov/pubmed/14502567
http://www.ncbi.nlm.nih.gov/pubmed/16879338
http://www.ncbi.nlm.nih.gov/pubmed/17385325
http://www.ncbi.nlm.nih.gov/pubmed/21916889
What can be done against too much FGF-5?
Sanguisorba Officinalis Root Extract (SO extract) has been shown to inhibit FGF-5 and reduced hair loss by causing prolongation of the anagen period.
Quote from the below linked article:
“In addition, in a clinical study using 39 volunteers with hair loss, the SO extract significantly decreased the telogen /anagen hair ratio and the number of shed hairs. This extract showed a high degree of usefulness clinically. These findings suggest that FGF-5-antagonizing activity of SO extract observed in vitro and in vivo is closely related to its clinical effects.”
Maeda et al.
Many hair loss sufferers, who use common products to battle their hair loss, are frustrated by unsatisfying results in form of tiny vellus hairs that resist to grow longer and thicker. The above presented data indicates that Garden Burnet Root Extract may be suitable to overcome this problem.

Grape Seed Extract (GSE) / Procyanidin B2, B3, C1
Grape Seed Extract contains the Procyanidins B2, B3 and C1.
Quotes from the below linked article:
“Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo.”
“After an extensive search, we discovered that proanthocyanidins extracted from grape seeds promote proliferation of hair follicle cells isolated from mice by about 230% relative to controls (100%); and that proanthocyanidins possess remarkable hair-cycle-converting activity from the telogen phase to the anagen phase in C3H mice in vivo test systems.”
http://www.ncbi.nlm.nih.gov/pubmed/9833041
Quotes from the below linked article:
“Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo.”
“Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% +/- 21.8% (mean +/- SD); procyanidin B-3, 80.9% +/- 13.0%; procyanidin C-1, 78.3% +/- 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%). In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth.”
http://www.ncbi.nlm.nih.gov/pubmed/10084307
Procyanidin-B2 is a constituent of Grape Seed Extract but it is also a constituent of apples.
Quotes from the below linked article:
“Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study“
“These results suggest that PKC isozymes, especially PKC-bI and -bII, play an important role in hair cycle progression and that the hair-growing mechanisms of procyanidin B-2 are at least partially related to its downregulation of PKC isozymes or its inhibition of translocation of PKC isozymes to the particulate fraction of hair epithelial cells.”
http://kimiara.com/download/Apple%20pol ... growth.pdf
Procyanidin-B3 is a constituent of Grape Seed Extract but it is also a constituent of Barley Extract.
Quote from the below linked article:
“Addition of TGF-beta1 to hair epithelial cell cultures dose-dependently decreased the cell growth, and addition of procyanidin B-3 to the culture neutralized the growth-inhibiting effect of TGF-beta1. From these results, it is concluded that procyanidin B-3 can directly promote hair epithelial cell growth in vitro, has the potential to counteract the growth-inhibiting effect caused by TGF-beta1 in vitro, and has potential to stimulate anagen induction in vivo.“
http://www.ncbi.nlm.nih.gov/pubmed/12473061
Title of the below linked article:
“Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms.”
http://www.ncbi.nlm.nih.gov/pubmed/16778458
Procyanidin-B3 has anti-inflammatory action.
Quote from the below linked article:
“The anti-inflammatory effect of procyanidin B3 (1) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears was examined. The anti-inflammatory activity of 1 was stronger than that of indomethacin and glycyrrhetinic acid, the normally used anti-inflammatory agents.”
http://www.ncbi.nlm.nih.gov/pubmed/20568787
Quote from the below linked article:
“Such results strongly suggest that ProB3 and RM-1 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis.”
http://www.ncbi.nlm.nih.gov/pubmed/21717518
Grape Seed Extract is an excellent antioxidant.
Quote from the below linked article:
“GSPE was also shown to upregulate bcl(2) gene and downregulate the oncogene c-myc. Topical application of GSPE enhances sun protection factor in human volunteers, as well as supplementation of GSPE ameliorates chronic pancreatitis in humans. These results demonstrate that GSPE provides excellent protection against oxidative stress and free radical-mediated tissue injury.”
http://www.ncbi.nlm.nih.gov/pubmed/10962138
Additional publications showing the anti-oxidant action of procyanidins:
http://www.ncbi.nlm.nih.gov/pubmed/17910615
http://www.ncbi.nlm.nih.gov/pubmed/22253995
Hair bleaching causes oxidative damage to the hair shafts. Procyanidin oligomers can protect the hair from oxidative damage and thereby exert a direct cosmetic effect on the already grown hair shaft.
Quote from the below linked article:
“In this study, several methods for evaluating oxidative damage in bleached hair are utilized to analyze the protective effect of procyandin oligomers against oxidative hair damage. It was observed that procyanidin oligomers strongly bind to keratin in hair and inhibit the breakdown of hair caused by oxidative damage in an analysis of hair using electrophoresis, transmission electron microscope, and fluorescence dye.”
http://www.ncbi.nlm.nih.gov/pubmed/21226878

Panax Ginseng Berry Extract (Fructus Panax Ginseng Extract [FPG Extract])
FPG Extract significantly elongated the anagen phase in C57BL/6 mice and elicited the proliferation of human dermal papilla cells by the upregulation of antiapoptotic bcl-2 accompanied by inhibition of apoptotic bax expression. 1% and even 0.1% of FPG Extract have been shown to be more effective than 5% Minoxidil.
Quote from the below linked article:
“More hair shafts were observed in FPG groups than minoxidil group as shown in Fig. 4.”
http://www.ncbi.nlm.nih.gov/pubmed/21959181
http://www.folikul.com/ginseng2.pdf
Role of the reduced Bcl-2/Bax ratio for apoptosis during hair follicle regression (catagen):
http://www.ncbi.nlm.nih.gov/pubmed/9403711
Anti-inflammatory action:
http://www.ncbi.nlm.nih.gov/pmc/article ... 490301.pdf
http://www.ncbi.nlm.nih.gov/pubmed/22849695
Ginsenosides exhibit a radioprotective effect and increase intracellular total antioxidant capacity:
http://www.ncbi.nlm.nih.gov/pubmed/12655795
http://www.ncbi.nlm.nih.gov/pubmed/19946576
Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice:
http://www.ncbi.nlm.nih.gov/pubmed/9627805
The contents of total ginsenoside and ginsenoside Re of Korean ginseng berry are significantly higher than those of Korean ginseng seed and American ginseng seed:
http://agris.fao.org/agris-search/searc ... 2009001089
The ginsenoside-Rb(1) has shown hair growth promoting activity and is a constituent of unprocessed ginseng berries:
http://www.ncbi.nlm.nih.gov/pubmed/12916080 http://www.boneandcancer.org/MOLab%20Pu ... /Wang%20et %20al_JAFC_Ginseng_12-28-06.pdf
Ginsenoside Ro and Rg(3) inhibit the 5α-reductase (5αR) and thereby enhanced in vivo hair re-growth in testosterone-treated C57BL/6 mice:
http://www.ncbi.nlm.nih.gov/pubmed/21538628
Topical application of ginsenoside Rb1 promoted angiogenesis during skin wound repair through stimulation of VEGF production and an increase in hypoxia-inducible factor (HIF-) 1α expression in keratinocytes: http://www.ncbi.nlm.nih.gov/pubmed/22505819
http://www.ncbi.nlm.nih.gov/pubmed/16770323
http://www.ncbi.nlm.nih.gov/pubmed/17600519

L-Arginine
L-Arginine upregulates Nitric Oxide (NO) expression and thereby increases blood flow to the hair follicles and decreases TGF-beta expression.
L-Arginine gets incorporated into hair shafts as a build block amino acid.
http://www.ncbi.nlm.nih.gov/pubmed/16239590
http://www.ncbi.nlm.nih.gov/pubmed/17728935
http://www.ncbi.nlm.nih.gov/pubmed/19841582

Taurine
Taurine promoted hair survival in vitro and prevented TGF-beta1-induced deleterious effects on hair follicle.
Taurine increases proliferation of so-called outer root sheet cells (ORS).
Oral intake of Taurine has been shown to increase the average hair diameter.
http://www.ncbi.nlm.nih.gov/pubmed/18489269
Poster P-189 on page 94: http://www.nahrs.org/home/Portals/0/mee ... ristol.pdf
http://www.ehrs.org/conferenceabstracts ... magara.htm
http://www.ncbi.nlm.nih.gov/pubmed/7773136

Biotin
Biotin is an essential micronutrient for normal cellular functions.
Biotin deficiency leads to pathologic dermatologic changes in the skin and its appendages.
http://www.ncbi.nlm.nih.gov/pubmed/22444695
http://www.ncbi.nlm.nih.gov/pubmed/12603856
http://www.ncbi.nlm.nih.gov/pubmed/20301497

Vitamin B12
Vitamin B12 works synergistically with Triaminodil.
http://www.ehrs.org/conferenceabstracts ... 4-park.htm

Ingredients
AQUA, DISODIUM LAURETHSULFOSUCCINATE, COCOMIDOPROPYL BETAINE, PEG-200 HYDROGENATED GLYCERYL PALMATE, PEG-7 GLYCERYL COCOATE, ALCOHOL DENAT., POLYSORBATE 20, PYRROLIDINIL DIAMINOPYRIMIDINE OXIDE, EPIGALLOCATECHIN GALLATE, SANGUISORBA OFFICINALIS ROOT EXTRACT, GRAPE SEED EXTRACT, PANAX GINSENG BERRY EXTRACT, PHENOXYETHANOL, ARGININE, TAURINE, BIOTIN, Vitamin B12

Directions of Use
Massage 1x daily (preferably in the morning) gently into wet hair, leave on for about 5 minutes, finally rinse off thoroughly. For best results use Capillogain® Shampoo in combination with Capillogain® Tonic.

Capillogain® Shampoo is for external use (topical application) only!
Do not use Capillogain® Shampoo if you are pregnant, think you might be pregnant or are breastfeeding!

curiousguy · Post by **curiousguy** » Tue Mar 12, 2013 7:19 pm

crap, have a batch from that lot and yes there is particulates in it. Guess I will contact them....pain for both of us.

Hordini · Post by **Hordini** » Tue Mar 12, 2013 10:46 pm

Is the Tria-free tonic still planned, and will there be a shampoo without it?

israelite · Post by **israelite** » Wed Mar 13, 2013 7:08 am

"This is slowly working for me. Getting some new regrowth in areas that haven't seen hair in 10 years. So much for Joe the zix guys 36 month theory. It's nothing crazy, just some new intermediate hairs and some new velous. I've been using this once per day for 4 months. Sorry no pics!" dopey3 from the private forum on stopaga

israelite · Post by **israelite** » Wed Mar 13, 2013 7:09 am

quite a few reports now with people with advanve hairloss seeing regrowth! simon, dopey, barbarea, and fuzz all have had some regrowth.

Jacob · Post by **Jacob** » Wed Mar 13, 2013 3:07 pm

The shampoo looks good...I just don't have room for it in my regimen at the moment.

SW2 · Post by **SW2** » Wed Mar 13, 2013 4:22 pm

4 days away from my 3 month mark with Capillogain, 2x ED. Almost finished my 4th bottle. Overall my hair looks worse than it did when i begun the trial mid-december. This past 5 weeks shedding and loss in general has been quite substantial; just this past week however, hair loss seems to have reduced to max 20 a day. I'm not sure if i'm reaching the end of a growth phase, but i will continue for a few months.

Synthese has already sent replacement bottles for the 3120005 batch. Can SyntheseLabRat explain what the differences were in this batch (as half of my trial was using this batch and half the first batch)? what was changed and why? should people with this batch dispose of remaining bottles when the replacement bottles arrive??

israelite · Post by **israelite** » Wed Mar 13, 2013 4:29 pm

Maybe its placebo or the minox but I'm definitely getting some action on the hair line. Including small dark hairs which could just be old hairs going into the growth phase but it has made me happy. campbell from blt.

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 4:42 pm

israelite wrote:"This is slowly working for me. Getting some new regrowth in areas that haven't seen hair in 10 years. So much for Joe the zix guys 36 month theory. It's nothing crazy, just some new intermediate hairs and some new velous. I've been using this once per day for 4 months. Sorry no pics!" dopey3 from the private forum on stopaga

Thank you very much for sharing these posts from the private forum, Mark.

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 4:51 pm

Hordini wrote:Is the Tria-free tonic still planned, and will there be a shampoo without it?

Yes, and I guess it will come soon. I voted for plain copy of Capillogain Tonic but just without the Triaminodil.
This has a big advantage compared to a changed formula. People will be able to judge the effect of Capillogain Tonic without the Triaminodil. Currently many people think this is just another overpriced Minox-product with some useless herbal extracts added in order to make the higher price plausible. But after people will report positive about the version without Triaminodil, nobody will be able to say that Capillogain is hiding behind the Minox-effect anymore. Well, luckily not many people are saying that at the moment anyway. And many people who are happy with their plain cheap Minox product so far will get a reason to use Capillogain in addition because they can add an additional effect to their regimen with Capillogain Tonic.
I am thinking of a name, maybe "Capillogain Tonic light" is a good idea.

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 4:57 pm

SW2 wrote:4 days away from my 3 month mark with Capillogain, 2x ED. Almost finished my 4th bottle. Overall my hair looks worse than it did when i begun the trial mid-december. This past 5 weeks shedding and loss in general has been quite substantial; just this past week however, hair loss seems to have reduced to max 20 a day. I'm not sure if i'm reaching the end of a growth phase, but i will continue for a few months.

Synthese has already sent replacement bottles for the 3120005 batch. Can SyntheseLabRat explain what the differences were in this batch (as half of my trial was using this batch and half the first batch)? what was changed and why? should people with this batch dispose of remaining bottles when the replacement bottles arrive??

It is better if my colleague gives you an answer to your question, you can pose your question here: service@functional-products.net

I give you the advice to use your new bottles.

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 5:03 pm

israelite wrote:Maybe its placebo or the minox but I'm definitely getting some action on the hair line. Including small dark hairs which could just be old hairs going into the growth phase but it has made me happy. campbell from blt.

Sounds good. Thank you Mark, I haven´t noticed this report so far.

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 5:14 pm

Jacob wrote:The shampoo looks good...I just don't have room for it in my regimen at the moment.

I think I haven´t stressed enough yet, that Capillogain Shampoo is one of very few Shampoos that gives the customer the possibility to use Triaminodil (nearly same chemical structure as Minoxidil) in a Shampoo. Actually I know only about one other Shampoo that contains Triaminodil/Minoxidil, which is from Proderma, our Triaminodil supplier.
Tonics are always more or less greasy and it is a hassle to use them, especially in the morning before on has to go to work. But many people shower in the morning anyways. A Shampoo doesn´t cause a residue, it does the opposite, it washes the hair and in addition Capillogain Tonic delivers many hair growth promoting ingredients to the scalp. Capillogain Shampoo gives the customer the possibility to use Triaminodil and additional active agents without the hassle with greasy Tonics. The effectiveness of the Triaminodil delivery to the scalp might be less with a Shampoo compared to a Tonic but every bit counts and with a Shampoo it is more convenient to reach every part of the scalp.
I like Shampoos

Capillogain Tonic is nearly not greasy at all compared to other products; however, I like Shampoos

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 5:41 pm

There are new reports at amazon:

----------------------------------------
"5.0 out of 5 stars Little greasy, March 2, 2013
By Javier Badillo - See all my reviews
This review is from: Capillogain® Tonic 100ml Anti-Hairloss System for men and women. Made in Germany (Misc.)
I notice a regrowth of my hairline 3 weeks after use. Don't smell nice but works and price is right!! Is greasy on hair, but benefits are nice."
----------------------------------------

But we received also our first negative report at amazon:

----------------------------------------
"2.0 out of 5 stars No benefit, March 7, 2013
By Slaw - See all my reviews
Amazon Verified Purchase(What's this?)
This review is from: Capillogain® Tonic 100ml Anti-Hairloss System for men and women. Made in Germany (Misc.)
Used it for about a month. Burned my scalp quite bad. No noticeable benefit at all. I ended up returning it. Was hoping for much more based on other reviews."
----------------------------------------

Well, he used it only for about a month. It is true that for some people it worked already after about 3 weeks but I think that is not the case for everyone.
From his other reviews I saw that he had no results from Lipogaine, too, although he used that one for 6 months; he seems to be a hardcore non-responder.

SyntheseLabRat · Post by **SyntheseLabRat** » Thu Mar 14, 2013 5:51 pm

israelite wrote:"This is slowly working for me. Getting some new regrowth in areas that haven't seen hair in 10 years. So much for Joe the zix guys 36 month theory. It's nothing crazy, just some new intermediate hairs and some new velous. I've been using this once per day for 4 months. Sorry no pics!" dopey3 from the private forum on stopaga

Mark, can you ask those users if they can post their reports in a public forum?
I would like to upload their comments on our testimonials page but they have to write them in a public forum by themselves; it is not enough if you post it.

israelite · Post by **israelite** » Fri Mar 15, 2013 12:22 am

SyntheseLabRat wrote:
israelite wrote:Maybe its placebo or the minox but I'm definitely getting some action on the hair line. Including small dark hairs which could just be old hairs going into the growth phase but it has made me happy. campbell from blt.
Sounds good. Thank you Mark, I haven´t noticed this report so far.

sorry for the confusion. this is actually campbell from badtruthtalk. he posted in the thread over there

SyntheseLabRat · Post by **SyntheseLabRat** » Fri Mar 15, 2013 1:48 am

israelite wrote:
SyntheseLabRat wrote:
israelite wrote:Maybe its placebo or the minox but I'm definitely getting some action on the hair line. Including small dark hairs which could just be old hairs going into the growth phase but it has made me happy. campbell from blt.
Sounds good. Thank you Mark, I haven´t noticed this report so far.
sorry for the confusion. this is actually campbell from badtruthtalk. he posted in the thread over there

There was no confusion, I already understood that. I just wanted to thank you, that you brought his post to our attention.

Jacob · Post by **Jacob** » Fri Mar 15, 2013 6:20 am

SyntheseLabRat wrote:
Jacob wrote:The shampoo looks good...I just don't have room for it in my regimen at the moment.
I think I haven´t stressed enough yet, that Capillogain Shampoo is one of very few Shampoos that gives the customer the possibility to use Triaminodil (nearly same chemical structure as Minoxidil) in a Shampoo. Actually I know only about one other Shampoo that contains Triaminodil/Minoxidil, which is from Proderma, our Triaminodil supplier.
Tonics are always more or less greasy and it is a hassle to use them, especially in the morning before on has to go to work. But many people shower in the morning anyways. A Shampoo doesn´t cause a residue, it does the opposite, it washes the hair and in addition Capillogain Tonic delivers many hair growth promoting ingredients to the scalp. Capillogain Shampoo gives the customer the possibility to use Triaminodil and additional active agents without the hassle with greasy Tonics. The effectiveness of the Triaminodil delivery to the scalp might be less with a Shampoo compared to a Tonic but every bit counts and with a Shampoo it is more convenient to reach every part of the scalp.
I like Shampoos
Capillogain Tonic is nearly not greasy at all compared to other products; however, I like Shampoos

Well now that you mention it- I was thinking about switching to the shampoo after my topical runs out, or even just using the topical here and there while using the shampoo regularly. So far I don't see any positive or negative results from the product, but I've been dabbling with hair loss experimentational

treatments for over a decade now, so wasn't really expecting too much. I think one needs to give things at least 6 months+ to really gauge if it's able to do anything. Unless of course one is shedding/losing hairs and it just won't stop.

Friday · Post by **Friday** » Sun Mar 17, 2013 4:50 am

Just a quick question about the the infamous bad batch; was it completely useless? Because I used it for about a month and been using from a newer batch for well over a month now, so in total I've been on cap for over two months, and I believe I'm beginning to see some results. Small, almost invisible hairs are showing in the frontal hairline, and I have been very very thin in that area for years now but now it looks like small hairs are filling in. Also vellus hairs in the corners of my hairline seem to be getting longer.

So I'm guessing the bad batch may have been doing something after all, or am I mistaken?

And also, great customer service! Got my replacement bottles a few days ago.

israelite · Post by **israelite** » Sun Mar 17, 2013 12:56 pm

getting strong regrowth! proof is in the youtub e video

http://www.youtube.com/watch?v=xo5PgaFAVCA

here is the old youtube videos

http://www.youtube.com/watch?v=uWCGKUkWDRA

HairyHarry · Post by **HairyHarry** » Mon Mar 18, 2013 12:19 am

israelite wrote:getting strong regrowth! proof is in the youtub e video

http://www.youtube.com/watch?v=xo5PgaFAVCA

here is the old youtube videos

http://www.youtube.com/watch?v=uWCGKUkWDRA

That's amazing! What are you using currently?

SyntheseLabRat · Post by **SyntheseLabRat** » Mon Mar 18, 2013 4:10 am

israelite wrote:getting strong regrowth! proof is in the youtub e video

http://www.youtube.com/watch?v=xo5PgaFAVCA

here is the old youtube videos

http://www.youtube.com/watch?v=uWCGKUkWDRA

Looks great!
I am not sure if I understand your video correct, but to me it looks like your former vellus hairs have grown much longer and are now hard to distinguish from your normal terminal hair. Is that correct? I mean I still see a difference but I followed your development for a long time; others may think your new hairs are just old hairs.

SyntheseLabRat · Post by **SyntheseLabRat** » Mon Mar 18, 2013 4:18 am

Friday wrote:Just a quick question about the the infamous bad batch; was it completely useless? Because I used it for about a month and been using from a newer batch for well over a month now, so in total I've been on cap for over two months, and I believe I'm beginning to see some results. Small, almost invisible hairs are showing in the frontal hairline, and I have been very very thin in that area for years now but now it looks like small hairs are filling in. Also vellus hairs in the corners of my hairline seem to be getting longer.

So I'm guessing the bad batch may have been doing something after all, or am I mistaken?

And also, great customer service! Got my replacement bottles a few days ago.

It is hard to tell. Some people report comparable results already after about 3 weeks and therefore your results may stem solely from the newer batch, but we don´t know that. However, since you seem to be a responder, I think your results will improve very much in the coming months.
I am happy that you are satisfied with our customer service. I am very happy with your initial results. Since you are a responder, you have good reason to be motivated.

israelite · Post by **israelite** » Mon Mar 18, 2013 6:49 am

SyntheseLabRat wrote:
Friday wrote:Just a quick question about the the infamous bad batch; was it completely useless? Because I used it for about a month and been using from a newer batch for well over a month now, so in total I've been on cap for over two months, and I believe I'm beginning to see some results. Small, almost invisible hairs are showing in the frontal hairline, and I have been very very thin in that area for years now but now it looks like small hairs are filling in. Also vellus hairs in the corners of my hairline seem to be getting longer.

So I'm guessing the bad batch may have been doing something after all, or am I mistaken?

And also, great customer service! Got my replacement bottles a few days ago.
It is hard to tell. Some people report comparable results already after about 3 weeks and therefore your results may stem solely from the newer batch, but we don´t know that. However, since you seem to be a responder, I think your results will improve very much in the coming months.
I am happy that you are satisfied with our customer service. I am very happy with your initial results. Since you are a responder, you have good reason to be motivated.

the new growth doesnt grow as fast. my hairline is much much stronger

SyntheseLabRat · Post by **SyntheseLabRat** » Mon Mar 18, 2013 7:28 am

israelite wrote:
SyntheseLabRat wrote:
Friday wrote:Just a quick question about the the infamous bad batch; was it completely useless? Because I used it for about a month and been using from a newer batch for well over a month now, so in total I've been on cap for over two months, and I believe I'm beginning to see some results. Small, almost invisible hairs are showing in the frontal hairline, and I have been very very thin in that area for years now but now it looks like small hairs are filling in. Also vellus hairs in the corners of my hairline seem to be getting longer.

So I'm guessing the bad batch may have been doing something after all, or am I mistaken?

And also, great customer service! Got my replacement bottles a few days ago.
It is hard to tell. Some people report comparable results already after about 3 weeks and therefore your results may stem solely from the newer batch, but we don´t know that. However, since you seem to be a responder, I think your results will improve very much in the coming months.
I am happy that you are satisfied with our customer service. I am very happy with your initial results. Since you are a responder, you have good reason to be motivated.
the new growth doesnt grow as fast. my hairline is much much stronger

Yes, fast results after about 3 weeks happen likely only for those who already had vellus hairs from e.g. Minox. For others it likely takes somewhat longer to see results.

israelite · Post by **israelite** » Mon Mar 18, 2013 8:55 am

@ syn
no my results have been slow bu steady. compare the youtube videos one is from september and the other from march

israelite · Post by **israelite** » Mon Mar 18, 2013 8:56 am

HairyHarry wrote:
israelite wrote:getting strong regrowth! proof is in the youtub e video

http://www.youtube.com/watch?v=xo5PgaFAVCA

here is the old youtube videos

http://www.youtube.com/watch?v=uWCGKUkWDRA
That's amazing! What are you using currently?

i use proxphen every other day
custom hairline serum 1 everyday
lipogaine
hairline serum 2 every other day
capillogain every day
ru most days

hermann · Post by **hermann** » Mon Mar 18, 2013 10:19 am

To Synthese:

Will there be an update of the progress of your colleague (47 years)?
His photo showed a lot of of vellus hairs.
How do they look like now?

Thank you.

SyntheseLabRat · Post by **SyntheseLabRat** » Mon Mar 18, 2013 6:09 pm

hermann wrote:To Synthese:

Will there be an update of the progress of your colleague (47 years)?
His photo showed a lot of of vellus hairs.
How do they look like now?

Thank you.

I will ask him for an update photo.

SyntheseLabRat · Post by **SyntheseLabRat** » Mon Mar 18, 2013 7:34 pm

updated testimonials page

http://www.functional-products.net/prod ... tonic.html

Aks20 · Post by **Aks20** » Tue Mar 19, 2013 1:26 am

Hi Synthese,

Any idea when the non triaminodil version of the Capillogain tonic would be available?
Looking forward to it eagerly.

Regarding a name, Capillogain Light is a great one. I want to use it regularly but the Minox effect is a huge problem.

MathGuy · Post by **MathGuy** » Tue Mar 19, 2013 8:36 am

Hi. Just started using Cap yesterday. I think someone mentioned this here before, but mL markers on the dropper would be really convenient. I'd prefer not to have to buy another pipette to measure this thing. If it's so important to keep the dosage within a certain range, then it should be imperative to have some standard marker on the pipette. Going by "pumps" is too ambiguous because different amounts are gathered per pump depending on how hard you pinch.

Other than that, so far no problems in the 2 applications I've had.

SyntheseLabRat · Post by **SyntheseLabRat** » Tue Mar 19, 2013 9:07 am

MathGuy wrote:Hi. Just started using Cap yesterday. I think someone mentioned this here before, but mL markers on the dropper would be really convenient. I'd prefer not to have to buy another pipette to measure this thing. If it's so important to keep the dosage within a certain range, then it should be imperative to have some standard marker on the pipette. Going by "pumps" is too ambiguous because different amounts are gathered per pump depending on how hard you pinch.

Other than that, so far no problems in the 2 applications I've had.

One normal pump equals about 1mL. We don´t expect a dramatic difference between the application of 0.7 or 1mL. However, of course it will be better if the dropper has mL marks. Hopefully we can offer such a dropper in the future.

MathGuy · Post by **MathGuy** » Tue Mar 19, 2013 9:36 am

SyntheseLabRat wrote:
MathGuy wrote:Hi. Just started using Cap yesterday. I think someone mentioned this here before, but mL markers on the dropper would be really convenient. I'd prefer not to have to buy another pipette to measure this thing. If it's so important to keep the dosage within a certain range, then it should be imperative to have some standard marker on the pipette. Going by "pumps" is too ambiguous because different amounts are gathered per pump depending on how hard you pinch.

Other than that, so far no problems in the 2 applications I've had.
One normal pump equals about 1mL. We don´t expect a dramatic difference between the application of 0.7 or 1mL. However, of course it will be better if the dropper has mL marks. Hopefully we can offer such a dropper in the future.

It's just that in the event that I do receive any side effects, I just want to be sure about the exact dosage I'm using so that I can lower my dosage appropriately. If I'm not experiencing sides, then it won't really matter.

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