Interview with Dr. Alex A. Khadavi, creator of Revivogen, (page 2)
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HairLossFight.com: Wow, that's a very optimistic timeline. I hope you're right with regard to that. I you involved directly with research into follicular neogenesis?
Kr. Khadavi: I was involved in [the cases of] two patients, but I did not directly do the study. I was witnessing what another doctor was doing with regards to follicular neogenesis. The great thing about follicular neogenesis [research] is that there are 4 laboratories which are doing the studies right now. There are 2 laboratories in the United States, there's one laboratory in Japan, and there is one laboratory in Europe, which are performing these studies. They all have the same basic idea and the same principles; however, there are little minor alterations in their methods, and hopefully one of them in the next few years is going to advance in the F.D.A. trials and hopefully come into Phase 2 and Phase 3 clinical trials.
One caveat however though is one of the laboratories which I cannot readily disclose has run into some problems in that when they had taken the injections and injected them into the front of the scalp they developed benign tumors. These are not necessarily cancers or skin cancers or hair follicular cancers but they were benign growths and so they [the undisclosed laboratory] are changing the principles of how they are growing the cells in the culture, and the growth factors which they are putting into the culture to stimulate these cells. So it's a little bit of a setback, but I still think that within the next 3 to 5 years we are going to have really solid advances in these studies, and hopefully within 5 years or so we are going to have it available to consumers.
HairLossFight.com: That would be a great thing. I have done some reading on it and it does seem like it is a very complex process. They were saying that it's about as complicated as trying to regrow limbs. So I hope you're right.
Dr. Khadavi: When we are born, all cells in the body have the potential to become anything. They can become brain cells, they can become skin cells, they can become hair cells, they can become kidney cells. Its the ability of our research to stimulate these cells and promote them to become either those hair cells or limb, or heart or kidney cells, and that's a complicated issue. That's why you need to have the right growth factors put in with the culture at the right times, and the correct sequence of growth factors, because if you don't do that correctly obviously you're going to develop bad cells and these benign tumors are going to grow somewhere or your limb is not going to grow correctly. Nature [requires] a very delicate balance of stimulants and stimulation at the right times to produce the right effects.
HairLossFight.com: Thanks for that prime on this topic. I truly hope that what you have said bears fruit. I'm sure that this is something good we all have to look forward to. Now, let's talk a bit to your Revivogen line of products. What are the key ingredients?
Dr. Khadavi:Well, Revivogen is a unique formula where we have taken all the known mechanisms of hair loss and addressed all of those mechanisms in one product. The reason why hair loss occurs is because of the conversion of testosterone into dihydrotestosterone or DHT which results in the miniaturization and ultimately the hair loss and hair being permanently gone. So what we have done with Revivogen is take these active ingredients, which are all-natural, inhibit the conversion of testosterone into DHT, much like the mechanism of Propecia yet make it in a natural formula that is used topically where it is not going into the rest of the body.
Those ingredients that are extremely powerful in inhibiting the conversion of testosterone into DHT are the fatty acids that we have. And the highest concentration of the fatty acids include the GLA [gamma-linoleic acid] and ALA [alpha-linoleic acid]. These have been shown to be the most powerful inhibitors of DHT production. Even more powerful than Propecia and as powerful as Dutasteride which is [also known by the drug name] Avodart. Now, another advantage of using these fatty acids, is not only that they are natural, but when they go throughout the body they get broken down so you don't have any systemic effect or any effect throughout the rest of the body [where it hasn't been applied]. Additionally we are delivering these right to the hair follicles, concentrating the active ingedients to the hair follicles and not not everywhere else. You don't have to take a handful of these ingredients by mouth in order to have the effects within your scalp.
The second mechanism that we address is, if there is any DHT left over, or any DHT within the circulation that comes into the hair follicle, we're blocking the DHT from attaching to the hair follicle. And this is basically what we call an androgen receptor blockage mechanism. This mechanism works by inhibiting any remnant DHT. The active ingredients include saw palmetto extract. These include Phytol, Ethyl Laurate, and Beta-Sito-Styrol. These are very powerful inhibitors of androgens to the hair follicle, particulary DHT.
The third, method of how Revivogen works is via stimulation of the hair into the anagen or growth phase. As you know, the longer the anagen phase the longer the hair grows, so the hairs that are miniaturized or baby or peach-fuzz hairs have a very low anagen phase. Those are hairs that have become suppressed by DHT. We have included Procyanid Oligomers and these procyanids stimulate the hair to go into anagen phase much like minoxidil does. All these three methods that we have discussed are included on our website, and all of these have been shown in peer review journals to do just what I have said here.
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