CB brainstorming thread.

[chore boy]

I just need a place to put stuff right now so I can have everything in front of me, in one location.

[chore boy]

I need to figure out what pathway or whatever brings the progenitor cells down to the DP... thinkin' I heard it might be stat3... I'm short on time right now.


Hmmm... I wonder if wounding deeply and trying to injure follicle and namely the DP would be enough to trick the progenitor cells into coming down to regenerate the DP? I wonder if in MPB, the senescent cells are keeping the DP from signaling the bulge for routine renewal (cycling) in a non-injury setting, but when there's an injury, the body's regenerative response is enough to override the senescent cells? That might explain that one story of the crazy guy who couldn't stop scratching his head and ended up regrowing hair where he was constantly scratching.

[chore boy]

[chore boy]

[chore boy]

a, Mammalian epidermal stem cells. A hair follicle and a segment of adjacent skin is illustrated. The dermal papilla (DP) signals to matrix stem cells (red) located across a basement membrane (green). Matrix cell daughters (yellow) differentiate into a variety of cell types, including the medulla, cortex and cuticle of the hair shaft (brown), the inner root sheath (IRS) and the outer root sheath (ORS). About two-thirds of the way up an anagen follicle lies the bulge — an expanded region that contains long-term stem cells (red). These cells periodically replenish (arrows) the matrix cells, and also help maintain the sebaceous gland (SG) and the epidermal stem cells (red, top layer) that lie against the basement membrane (not shown) overlying the basal layer in interfollicular regions. b, A mammalian gut crypt is a tube of cells arrayed on a basement membrane (green). Stem cells (red) are located in the basal region along with Paneth cells, but their exact location is variable and both types account for only a fraction of the cells present in the regions shown. A portion of the basement membrane in the stem cell region may be specialized (dark green). Stem cell progeny (yellow) known as transit amplifying cells (TA) move upwards and differentiate. Underlying mesenchymal cells (green) send signals that help regulate stem cell activity.

[chore boy]